THERAPEUTIC PLASMA EXCHANGE
An oil changefor your biology.
TPE removes inflammatory proteins, autoantibodies, and toxins from your blood, replacing them with clean albumin in a single 90-minute session.
WHY IT MATTERS
What is Therapeutic Plasma Exchange?
Your plasma accumulates what your body can't fully clear on its own: inflammatory proteins, autoantibodies, metabolic waste, and environmental toxins. Over time, that burden drives chronic inflammation, immune dysfunction, and diminished cellular performance.
TPE separates plasma from your blood cells, removes the compromised portion, and replaces it with pharmaceutical-grade albumin. Your refreshed blood is returned to your body, with less of what was slowing it down.
It's a direct intervention, not a downstream one. And that's what makes the shift feel different.
- [ Clinically Supervised ]
- [ Personalized Protocols ]
- [ Measurable Results ]
HOW IT WORKS
How TPE Works
From blood draw to refreshed baseline, start to finish in 90 minutes.
Your provider reviews your health history, vitals, medications, and hydration status to confirm you're a good candidate.
Blood is drawn and circulated through an FDA-cleared filtration device that separates plasma from blood cells.
The plasma portion is removed and replaced with pharmaceutical-grade albumin, preserving essential blood components.
Your refreshed blood is returned to your body. Plan for 24 hours of rest, hydration, and light activity.
MEASURABLE OUTCOMES
Measurable changes. Across three domains
Most therapies work downstream. TPE goes directly to the source, which is why the shift happens faster.
- 01
Less Inflammation
Circulating inflammatory proteins drop significantly, reducing the systemic load behind chronic fatigue, immune dysregulation, and persistent symptoms.
- 02
Mental Clarity
Lower neuroinflammatory burden means cleaner signal. Sharper focus, faster recall, and a noticeable lift in cognitive function.
- 03
Cellular Renewal
By reducing what your cells constantly work against, TPE creates conditions where repair and regeneration can actually happen.
How to know ifTPE is right for you
A consultation confirms fit. This gives you a starting point.
Ideal For
- Individuals seeking health optimization
- Those managing chronic inflammation
- Persistent brain fog or low energy
- Experiencing immune dysregulation
- High inflammatory markers on bloodwork
Not ideal for
- Active infections
- Severe anemia or coagulation disorders
- Advanced heart disease
- Uncontrolled autoimmune disorders
- Poor venous access
Disclaimer:Every individual is different. A consultation with your Humanaut Health provider is the best way to determine whether TPE is right for your goals.
EXPERT PERSPECTIVE
“For individuals seeking to optimize general health, improve autoimmune symptoms, or support detoxification at a cellular level, TPE is a transformative therapy. It represents the kind of advanced, evidence-based approach that defines what we do at Humanaut Health.”
Amy Killen, MD
Chief Medical Officer and Co-Founder
CLINICAL FOUNDATION
The science behind TPE
Therapeutic Plasma Exchange targets the plasma component of blood, where inflammatory cytokines, autoantibodies, and toxins circulate. By removing this plasma and replacing it with pharmaceutical grade albumin, the therapy directly reduces the concentration of harmful compounds while preserving essential blood components.
This results in a rapid decrease in immune system activation and inflammatory signaling. Because the intervention acts on circulating drivers rather than downstream symptoms, it can create a more immediate shift in physiological state compared to therapies that rely on gradual metabolic change.
Frequently paired with
- [ EBO2 ]
- [ NAD+ ]
- [ Advanced Health Check ]
Good Questions
No guesswork. Just clarity.
Therapeutic Plasma Exchange is a medical procedure that removes plasma from the blood and replaces it with a clean albumin solution to eliminate inflammatory proteins, toxins, and autoantibodies. It is used to reduce immune system overactivity and systemic inflammation.
Therapeutic Plasma Exchange works by separating plasma from blood cells, removing the plasma that contains harmful compounds, and replacing it with pharmaceutical grade albumin before returning the blood to the body.
The benefits of Therapeutic Plasma Exchange include reduced inflammatory burden, improved immune regulation, removal of circulating toxins and antibodies, and support for neurological and systemic function.
Therapeutic Plasma Exchange is a well-established medical procedure performed in controlled clinical settings with trained staff and specialized equipment. When administered appropriately, it is considered safe and effective.
The removed plasma is replaced with pharmaceutical grade albumin. This maintains proper blood volume and protein balance while allowing harmful compounds to be removed from circulation.
Therapeutic Plasma Exchange removes and replaces plasma to eliminate inflammatory and immune-related compounds. EBO2 focuses on oxygenation and filtration of blood. TPE targets immune drivers directly, while EBO2 supports oxygen delivery and cellular function.
TPE is most appropriate for individuals with autoimmune activity, high inflammatory burden, toxin exposure, or complex conditions driven by immune dysfunction.
You can, but outcomes are stronger when TPE is used within a broader care plan that identifies and addresses the underlying drivers of inflammation and immune dysfunction.
Some individuals experience noticeable changes shortly after treatment, particularly in inflammation and cognitive clarity. More durable improvements typically occur across multiple sessions.